Transdermal Research Pharm Lab
Long Island City (NY) and Paramus (NJ)
Research Services
TRPL provides one-stop research services for the development of transdermal/topical formulations
Preliminary Laboratory Feasibility Studies
- Development and validation of analytical methods
- Pre-formulation studies
- Formulation Development
- Expertise for 1-to-7-day transdermal drug delivery
- Expertise for topical drug delivery
- Solubility studies
- Selection of excipients and enhancers
- In vitro flux studies
- Human cadaver skin
- Animal skin
- Synthetic membranes
Optimization for preliminary product development
- Short term stability studies
- Extended formulation development to
- Optimize permeation
- Determine chemical stability
- Optimize physical properties of formulation
- Cold flow
- Cohesion of laminates
- Skin adhesion
- Rheology
- Particle size distribution
- Viscocity
- Morphology
- pH
Instruments
- 200+ Franz-diffusion cells
- Semi-automated USP VII Dissolution apparatus
- HPLC Systems (DAD equipped)
- Differential Scanning Calorimeter
- Rheometer
- Texture Analyzer
- Semi-automated Film Applicator
- Ovens
- Temperature control chambers
- Laminator
- Polarize Microscope
- Freezer (-80C)
Management of Pre-clinical Studies (outside contractors)
- Pharmacokinetic parameters
- Skin irritation and sensitization
Licensing
- NYS DEA schedule I-IV license for research and manufacturing
